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Vitiligo is a chronic skin disease characterized by the appearance of white spots with precise contours on various body parts. These depigmented spots are due to the destruction of melanocytes - the cells responsible for skin pigmentation. Depigmentation may be more or less important, and the affected areas have a variable size, that's way vitiligo skin may be a devastating condition for anybody.
The origin of the disease is unknown, but it is believed that it is an autoimmune disease where the body produces antibodies to attack and destroy their own melanocytes.
Vitiligo appears first as small depigmented spots, which spread and grow in size over time. These changes of the skin lead to patient the occurence of stress and anxiety due to the unsightly appearance.
Vitiligo pictures in children
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Vitiligo affects 1% - 2% of the population and usually occurs before the age of 20 years (50% of people affected). There is no cure for vitiligo. Instead, the goal of treatment is to stop or slow depigmentation and to return the skin coloration within certain limits. In rare cases, the spots disappear on their own. People affected by vitiligo have an increased risk of skin cancer because the depigmented areas are not protected against sunlight.
Vitiligo pictures face
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Vitiligo disease is a pigmentosa condition of the mucous membranes and of the skin, and has as characteristics some circumscribed depigmented patches and macules. It is a progressive condition where some parts or even all of the lesioned skin melanocytes are destroyed in a selective way. This disorder affects about 2% of the population and the age when this disease appears is 20 years. Vitiligo symptoms are as well as the ones as a multifactorial disease with a very complex pathogenesis. In order to better understand this concept, see here some vitiligo pictures.
Vitiligo manifests as macules or white hypo-pigmented spots. This disease has a relation to genetic and non genetic factors. The exact cause of this condition remains unknown, even though there were plenty proposed theories. Principles are generally accepted when there is a lack of functional melanocytes in affected skin and loss of histochemical recognition of melanocytes leading to their elimination.
Vitiligo cosmetics pictures
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There is not a single therapy that causes good results, meaning there is not a vitiligo cure. The response to therapy is quite variable. Vitiligo treatment should be individualized and patients should be aware of the risks associated with therapy. Phototherapy induces systemic satisfactory cosmetic repigmentation in 70% of patients with early or localized disease. Laser therapy is another innovation for limited spots vitiligo, stable. Therapy is still expensive. Steroid therapy with prednisone was used although the prolonged administration and its toxicity are undesirable. Benefits should be assessed carefully against the toxicity. Topical therapy with tacrolimus creams are an alternative option for vitiligo cure.
Vitiligo Michael Jackson pictures
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If this condition is widespread and vitiligo repigmentation attempts have not given satisfactory results can be tried depigmentation in some patients. There are alternatives to surgical vitiligo treatment, however due to time-consuming nature of these therapies are limited for the localized vitiligo.
Theories on the autoimmune elimination of melanocytes can include the mechanisms, cytotoxic mechanisms, and intrinsic defects of melanocytes, neural mechanism and oxidation-reducing mechanisms. Due to the pathogenesis of this disorder, there is not a vitiligo treatment to give a 100% recovery.
Vitiligo pictures before after
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There is some autoimmune theory which suggests altered cellular and humoral immune elimination of melanocytes in vitiligo disease. Thyroid disease, especially Grave's diseas and Hashimoto thyroiditis and other endocrinopathies like diabetes and Addison's disease, alopecia areata, autoimmune poliglandular syndrome, intestinal inflammatory disease, psoriasis and pernicious anemia are in the same category with vitiligo Michael Jackson, the disease which make the star becoming white. There are important evidences of autoimmune pathogenic circulating antibodies are prevalent in persons affected of vitiligo skin. Humoral immunity has an important role which is sustained through the observation of melanocytes eliminated in healthy, normal skin grafts in a patient with vitiligo.
Here are some vitiligo pictures which will make you understand what this condition involves.
Vitiligo pigmentation pictures
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Beside the mechanisms involved in the humoral autoimmune vitiligo's pathogenesis and indicate the implication of cellular immunity. CD 8 lymphocytes can mediate directly the elimination of melanocytes.
Melanocytes in vitiligo can have a defect, an intrinsic defect leading to serious health problems. The melanocytes show different abnormalities, including the uncommon endoplsmic reticulum, rough and the processing melanocytes and incomplete synthesis. Therfore there were detected and receptor abnormalities. The cause of melanocytes low survival can be their early apoptosis; however, a second investigation reveals that there is a relative susceptibility to the apoptosis of the melanocytes which were comparable to the healthy ones.
Vitiligo symptoms pictures
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Oxidative stress also plays a role in vitiligo pathogenesis. Due to the fact that patients suffering of vitiligo show a characteristic fluorescent yellow / green or blue of the skin clinically affected, this lead to the detection of this next fact: fluorescence exist because of the accumulation of oxygen radicals. Pteridine production leads to accumulation of hydrogen peroxide melanocitotoxic.
Neural theory in vitiligo refers to patients with nerve damage and vitiligo which shows skin depigmentation or hypopigmentation in the area without nerves. Segmental vitiligo suggests that some chemical mediators are being released into the depigmented spots of this disorder with increased adrenergic activity.
Vitiligo skin pictures
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Incomplete penetration and the genetic heterogeneity are the characteristics of vitiligo skin. There are genes associated with melanin biosynthesis, being a feedback to the regulating autoimmunity and oxidative stress.